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Target intelligence / Profile preview
Gastric H+,K+-ATPase (H+,K+-ATPase)
- Target
- H+,K+-ATPase
- Molecular classification
- Enzyme, P-type ATPase, Transporter
01
Overview
Gastric H+,K+-ATPase is a membrane-bound enzyme complex responsible for acidifying the stomach contents. It is an alpha,beta-heterodimeric enzyme that exchanges intracellular hydronium ions (H+) with extracellular potassium ions (K+) using ATP. It is primarily found in parietal cells of the stomach lining and is the target of proton pump inhibitors (PPIs), a major class of drugs used to treat acid-related diseases.
- Other names
- Hydrogen potassium ATPaseProton pumpGastric proton pump
02
Mechanism of action
Irreversible inhibition of the gastric H+,K+-ATPase, blocking gastric acid secretion.
03
Biological functions
Gastric acid secretionIon transport
04
Disease associations
Peptic ulcerGastroesophageal reflux disease
05
Safety considerations
Long-term use associated with increased risk of certain infections (e.g., Clostridium difficile)Potential for nutrient malabsorption (e.g., vitamin B12, magnesium)Possible increased risk of bone fractures with long-term use
06
Interacting drugs
Omeprazole
5 more in the full profile.
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