Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Hydrogen-potassium ATPase (H⁺/K⁺-ATPase)
- Target
- H⁺/K⁺-ATPase
- Molecular classification
- P-type ATPase, P2-type ATPase, Enzyme, Transporter
01
Overview
Hydrogen-potassium ATPase plays a central role in digestive physiology through its unique ability to generate highly acidic conditions within the stomach while maintaining cellular ionic balance. Its structure-function relationship underpins both normal gastrointestinal function and therapeutic intervention strategies targeting excessive or pathological acid production.
- Other names
- Gastric proton pumpProton pump
02
Mechanism of action
Covalent binding to cysteine residues of H⁺/K⁺-ATPase, inhibiting its activity and reducing gastric acid secretion.
03
Biological functions
Gastric acid secretionPotassium reabsorptionAcid-base balanceDigestionDefense against ingested pathogens
04
Disease associations
Gastroesophageal reflux disease (GERD)Peptic ulcersZollinger-Ellison syndrome
05
Interacting drugs
Proton pump inhibitors (PPIs)
Beyond the preview
Go deeper on Hydrogen-potassium ATPase (H⁺/K⁺-ATPase).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Hydrogen-potassium ATPase (H⁺/K⁺-ATPase).