Gastric volume reduction via partial gastrectomy

Gastric volume reduction via partial gastrectomy refers to a surgical procedure—most commonly the sleeve gastrectomy—in which a significant portion of the stomach is surgically removed. This results in a smaller gastric reservoir, directly restricting food intake and promoting early satiety. Beyond mechanical restriction, this intervention leads to complex physiological changes including reduced secretion of ghrelin (the hunger hormone), increased satiety hormones, altered gastrointestinal motility, shifts in gut microbiota composition, and changes in nutrient metabolism. These combined effects contribute not only to sustained weight loss but also improvement or remission of obesity-related comorbidities such as type 2 diabetes mellitus, hypertension, dyslipidemia, and obstructive sleep apnea. However, "gastric volume reduction via partial gastrectomy" is not itself a molecular target but rather describes a surgical technique; thus it does not fit standard definitions for therapeutic targets like receptors or enzymes.

Other names

Sleeve gastrectomyLaparoscopic sleeve gastrectomyVertical sleeve gastrectomyPartial gastrectomy for obesity treatment