Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Gastrin
- Molecular classification
- Peptide hormone
01
Overview
Gastrin is a peptide hormone produced primarily by G cells in the lining of the stomach (specifically, the antrum). It plays a central role in regulating digestive processes, especially those related to gastric acid secretion and gastrointestinal motility. Gastrin’s primary functions include stimulating parietal cells of the stomach to secrete hydrochloric acid, promoting conversion of pepsinogen to pepsin, enhancing gastric motility and stimulating growth of gastric mucosa.
02
Mechanism of action
Gastrin stimulates parietal cells to secrete HCl, both directly and indirectly through ECL cells. PPIs inhibit the H+/K+ ATPase pump on parietal cells, reducing acid secretion. H2-receptor antagonists block histamine receptors on parietal cells. Somatostatin analogs inhibit gastrin release from G cells.
03
Biological functions
Stimulation of hydrochloric acid (HCl) secretionPepsinogen conversion to pepsinEnhancement of gastric motilityStimulation of gastric mucosa growthPancreatic enzyme secretionGallbladder contraction
04
Disease associations
Zollinger-Ellison syndromeChronic atrophic gastritisHypochlorhydria/AchlorhydriaGastric cancer (indirectly, through trophic effects)
05
Safety considerations
Long-term PPI use can lead to hypergastrinemia and potential trophic effects on gastric mucosa.Gastrinomas can cause severe peptic ulcer disease and diarrhea.
06
Interacting drugs
Proton pump inhibitors (PPIs)
2 more in the full profile.
07
Biomarkers
Serum gastrin levels
Beyond the preview
Go deeper on Gastrin.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Gastrin.