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Gastrointestinal detoxification pathway
- Molecular classification
- Other (multiple enzymes, transporters, not a single class)
01
Overview
Gastrointestinal detoxification pathways are complex networks by which the gut and liver process, modify, and eliminate toxins. These involve physical and enzymatic barriers, microbial metabolism, and hepatic biotransformation, and support overall systemic detoxification and health. Disruption can lead to various chronic diseases.
- Other names
- Detoxification pathways in GI tractGut-liver axis detoxificationGI detoxification processes
02
Mechanism of action
CYP450 oxidation/reduction; Conjugation (glucuronidation, etc.); Microbial biotransformation
03
Biological functions
Metabolic biotransformationBarrier functionWaste eliminationXenobiotic detoxificationBile acid recyclingMicrobial metabolite modification
04
Disease associations
InflammationLiver diseaseCancerInfectionMetabolic diseaseDysbiosis-related disorders
05
Safety considerations
Drug interactions (CYP450)DysbiosisLeaky gutImpaired liver conjugation capacity
06
Interacting drugs
Prescription drugs metabolized by CYP450s
1 more in the full profile.
07
Biomarkers
Bile acid compositionLiver enzymesGlutathioneMicrobial diversityMarkers of intestinal permeability
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