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Target intelligence / Profile preview
Gastrointestinal Epithelial Cell Membrane (GI Epithelial Cell Membrane)
- Target
- GI Epithelial Cell Membrane
- Molecular classification
- Membrane, Cellular Structure, Lipid Bilayer, Receptor, Transporter, Enzyme
01
Overview
The gastrointestinal (GI) epithelial cell membrane is the plasma membrane of cells lining the GI tract, forming a selective barrier for nutrient absorption, secretion, and immune defense. It comprises various cell types like enterocytes, goblet cells, and Paneth cells, organized with apical microvilli and tight junctions. Its functions include selective nutrient absorption, secretion of mucus and antimicrobial factors, and physical barrier against pathogens. Disruption of this membrane is implicated in diseases like inflammatory bowel disease.
- Other names
- Intestinal Epithelial Cell MembraneGut Epithelial Cell MembraneGI Barrier
02
Mechanism of action
Modulation of membrane permeability, receptor signaling, or transporter activity; protection of the epithelial barrier; modulation of immune response
03
Biological functions
Nutrient absorptionSecretionBarrier functionImmune signalingCell adhesionSelective transportHomeostasis maintenanceSignalingChemoreception
04
Disease associations
Inflammatory Bowel DiseaseLeaky Gut SyndromeInfectionCancerMalabsorptionAutoimmune Diseases
05
Safety considerations
Disruption of barrier functionIncreased intestinal permeabilityDysbiosisDrug-induced enteropathyCompromised nutrient absorption
06
Interacting drugs
Anti-inflammatory drugs
4 more in the full profile.
07
Biomarkers
ZonulinLipopolysaccharide (LPS)Fecal calprotectinIntestinal permeability markersCytokine levelsTight junction proteins
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