Gastrointestinal homeostasis pathways

"Gastrointestinal homeostasis pathways" refers to the collective network of signaling, immune, metabolic, and neural processes that maintain the balance and normal function of the digestive tract[1][2][3][6]. These include the gut–brain axis, gut microbiota, endogenous peptide hormones (e.g., GLP-1, PYY), neural circuits (ENS), immune surveillance, epithelial barrier function, and nutrient-sensing systems[1][2][4][5][6]. Dysregulation can contribute to disease states including metabolic syndrome, diabetes, inflammatory bowel disease, and more[1][2][4][6]. However, as defined, the term is overly broad and not suitable for listing as a specific target for drug intervention; rather, it provides a conceptual framework for understanding the integrated regulation of GI health and disease.

Other names

intestinal homeostasis pathwaysgut homeostasis mechanisms