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Gastrointestinal microbiome modulation
- Molecular classification
- Biological process, Therapeutic strategy
01
Overview
Gastrointestinal microbiome modulation refers to the intentional alteration of the composition, diversity, or activity of the microbial community within the gastrointestinal (GI) tract. This process aims to improve host health by influencing various physiological functions, including metabolism, immune regulation, and protection against pathogens. Strategies include dietary interventions, prebiotics, probiotics, antibiotics, post-biotics, and fecal microbiota transplantation.
- Other names
- Gut microbiota modulationIntestinal flora manipulation
02
Mechanism of action
Modulation of the gastrointestinal microbiome through dietary interventions, prebiotics, probiotics, antibiotics, post-biotics, or fecal microbiota transplantation to alter the composition, diversity, or activity of the microbial community within the gastrointestinal (GI) tract, aiming to improve host health.
03
Biological functions
Alters microbial community structure/functionInfluences metabolic/immunological homeostasis
04
Disease associations
Dysbiosis-related disordersInflammatory bowel diseaseObesity/metabolic syndrome
05
Safety considerations
Inter-individual variability in response to interventionsPotential for dysbiosis from broad-spectrum antibioticsRisk of infection from fecal microbiota transplantation
06
Interacting drugs
Prebiotic fibers/resistant starches
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