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Gastrointestinal Smooth Muscle (GI Smooth Muscle)
- Target
- GI Smooth Muscle
- Molecular classification
- Smooth Muscle Tissue
01
Overview
Gastrointestinal (GI) smooth muscle refers to the specialized, involuntary muscle tissue that forms the muscular layers of the digestive tract. It is responsible for generating the movements necessary for digestion, including peristalsis and segmentation. Its function is regulated by intrinsic electrical activity, neural inputs from the enteric nervous system, and hormonal factors.
- Other names
- Digestive Smooth MuscleGut Smooth MuscleIntestinal Smooth MuscleVisceral Smooth Muscle (in GI tract)
02
Mechanism of action
N/A (Tissue, not a specific protein)
03
Biological functions
PeristalsisSegmentationTonic contractionRegulation of GI motilityMixing of luminal contentsPropulsion of contents through GI tractAbsorptionSphincter controlMechanotransduction
04
Disease associations
Gastrointestinal motility disordersIrritable Bowel Syndrome (IBS)Inflammatory Bowel Disease (IBD)GastroparesisConstipationDiarrheaAchalasiaHirschsprung's diseaseVisceral pain
05
Safety considerations
Drug-induced alterations in GI motility (e.g., constipation, diarrhea)Smooth muscle spasmIleusAdverse effects related to altered drug absorption
06
Interacting drugs
Acetylcholinesterase inhibitors
6 more in the full profile.
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