Gastrointestinal system function modulation

Gastrointestinal system function modulation" refers to the therapeutic concept of altering any aspect of GI system physiology, including motility, secretion, absorption, immune response, and barrier function via molecular, cellular, or microbial targets. It is not a discrete target like a receptor or enzyme, but rather an umbrella term describing a range of potential interventions on multiple molecules, such as neurotransmitter receptors (e.g., glutamate receptors, serotonin receptors), immune mediators (e.g., interleukins, tumor necrosis factor-alpha), enzymes (e.g., cytochrome P450s), transporters (e.g., MDR1, MRPs), transcription factors (e.g., aryl hydrocarbon receptor, pregnane X receptor), and interactions with gut microbiota.