Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Gastrokine-1 (GKN1)
- Target
- GKN1
- Molecular classification
- Secreted protein, BRICHOS domain-containing protein
01
Overview
Gastrokine-1 (GKN1) is a highly conserved, protease-resistant, secreted protein encoded by the GKN1 gene, expressed predominantly in the gastric foveolar epithelial cells and restricted to the stomach mucosa. It maintains gastric mucosal integrity, regulates cell proliferation, differentiation, and repair, and suppresses inflammatory signaling pathways (e.g., NF-κB, COX-2). The BRICHOS domain mediates protein-protein interactions and is associated with suppression of cancer and prevention of amyloid aggregation. Gastrokine-1 has been implicated as a tumor suppressor, with loss of expression linked to the development and progression of gastric cancer.
- Other names
- AMP-18CA11FoveolinTFIZGastrokine 1 proteinGKN1
02
Mechanism of action
no therapies target GKN1 directly; its mechanism is endogenous—acts via its BRICHOS domain and cellular interactions
03
Biological functions
Maintenance of gastric mucosal integrityRegulation of cell proliferation and differentiation in gastric tissueSuppression of inflammation (regulating cytokine production, suppressing NF-κB and COX-2 signaling)Anti-amyloidogenic (prevention of amyloid formation)
04
Disease associations
Gastric cancer (acts as a tumor suppressor; expression lost in cancer)Gastric inflammationOther potential roles in metabolic regulation and obesity, but not confirmed as a classical disease mechanism
05
Biomarkers
Gastrokine-1 expression levels (proposed as biomarker for normal gastric mucosa vs gastric cancer)
Beyond the preview
Go deeper on Gastrokine-1 (GKN1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Gastrokine-1 (GKN1).