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GCC2 antisense RNA 1 (GCC2-AS1)
- Target
- GCC2-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Antisense RNA, Other
01
Overview
GCC2 antisense RNA 1 (GCC2-AS1) is a long non-coding RNA (lncRNA) gene located on chromosome 2q12.3, transcribed antisense to the GCC2 gene[2][3]. It does not encode a protein but acts as a regulator of gene expression, most likely influencing the expression of the sense GCC2 gene by forming sense-antisense RNA pairs[4]. GCC2-AS1 is significantly upregulated in lung adenocarcinoma tissue compared to normal tissue, where its higher expression is strongly associated with increased cancer cell proliferation, invasion, and poor prognosis in patients[2]. GCC2-AS1 has been proposed as both a diagnostic and prognostic biomarker for lung adenocarcinoma, though its precise molecular pathways are still being determined. There are currently no drugs known to directly target GCC2-AS1, and it is not considered a receptor, enzyme, or classic therapeutic target, but rather a cancer-associated regulatory RNA[2][3][4].
- Other names
- GCC2-AS1GRIP and coiled-coil domain-containing protein 2 antisense RNA 1
02
Biological functions
Regulation of gene expressionRegulation of cell proliferationRegulation of cell invasionOther
03
Disease associations
Cancer, specifically Lung adenocarcinoma (LUAD), possibly other solid tumors
04
Biomarkers
Prognostic biomarker for lung adenocarcinomaDiagnostic biomarker for lung adenocarcinoma
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