GDF5 antisense RNA 1 (GDF5-AS1)

GDF5 antisense RNA 1 (GDF5-AS1) is a long non-coding RNA gene located antisense to the GDF5 gene, which encodes growth differentiation factor 5, a member of the BMP family involved in cartilage and bone formation[5]. GDF5-AS1 itself does not encode a protein and is thought to play a regulatory role by modulating the transcription, stability, or translation of messenger RNA from the GDF5 gene through antisense RNA mechanisms[5]. There are currently no direct reports linking GDF5-AS1 to disease, biomarkers, or drug interactions. The molecule’s relevance is in the regulatory layer of gene expression and its potential future utility as an RNA-targeted therapeutic or diagnostic marker. Most recent evidence and disease association relate to other antisense lncRNAs such as FGD5-AS1, not GDF5-AS1[4][6].

Other names

GDF5OSGDF5 antisense RNA 1Growth/differentiation factor 5 opposite strand transcript

Not applicable for drugs, as no direct drug interactions are documented.