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GDNF family receptor alpha-2 (GFRA2)
- Target
- GFRA2
- Molecular classification
- Receptor, GPI-anchored cell surface receptor, Glial cell line-derived neurotrophic factor receptor family
01
Overview
GDNF family receptor alpha-2 (GFRA2) is a glycosylphosphatidylinositol (GPI)-anchored cell surface receptor that preferentially binds the neurotrophic factor neurturin and also interacts with glial cell line-derived neurotrophic factor (GDNF). GFRA2 mediates the activation of the RET tyrosine kinase receptor and supports signaling pathways involved in the survival and differentiation of sympathetic and other neurons. The protein and its gene have been implicated in neurodevelopmental and neurodegenerative diseases as well as certain cancers, notably neuroblastoma. GFRA2 is distinct from its family members by its ligand specificity and physiological roles.
- Other names
- Neurturin receptorGDNFRBRETL2TRNR2GDNF receptor alpha-2GDNFR-alpha-2GFR-alpha-2GDNFR-betaNRTNR-alphaNTNR-alphaNTNRATGF-beta-related neurotrophic factor receptor 2PI-linked cell-surface accessory proteinTRN receptorglial cell line-derived neurotrophic factor receptor betaneurturin receptor alpha
02
Mechanism of action
Ligand binding (especially neurturin): interaction with neurturin leads to complex formation with the RET tyrosine kinase, triggering downstream signal transduction and impacting neuronal survival
03
Biological functions
Signal transductionNeurotrophic signalingRegulation of neuron survival and differentiation
04
Disease associations
Neurodegenerative diseaseCardiovascular diseaseCancer/neuroblastoma (association)Hirschsprung diseaseRetinal degeneration
05
Safety considerations
Potential off-target effects in nervous system due to widespread role in neuronal maintenance and differentiation, especially if targeted by agonists or antagonists (inferential; not directly stated in sources)
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