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Target intelligence / Profile preview
GDNF Family Receptor Alpha-3 (GFRα3)
- Target
- GFRα3
- Molecular classification
- Receptor, Glycosylphosphatidylinositol (GPI)-anchored cell surface receptor, GDNF receptor family, Extrinsic tyrosine kinase receptor
01
Overview
GDNF Family Receptor Alpha-3 (GFRα3) is a GPI-anchored cell surface receptor and a member of the GDNF receptor family. It binds primarily to artemin (ARTN) and forms a signaling complex with the RET tyrosine kinase receptor, mediating downstream signaling pathways involved in nervous system development, neuron survival, and sensory nerve function. It is also expressed in pancreatic endocrine progenitors and has been implicated in cancer and pain pathways.
- Other names
- GFRA3GDNFR3artemin receptor
02
Mechanism of action
GFRα3 forms a signaling complex with the RET tyrosine kinase receptor upon binding to Artemin, mediating artemin-induced autophosphorylation and activation of RET, and initiating downstream pathways like MAPK signaling cascades.
03
Biological functions
Signal transductionNeuron survivalAxon guidanceNervous system developmentSensory nerve functionPancreatic innervationEndocrine differentiation
04
Disease associations
Breast cancerProstate cancerBreast duct papillomaFamilial medullary thyroid carcinomaOsteoarthritis pain
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