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GDNF-inducible zinc finger protein 1 (GZF1)
- Target
- GZF1
- Molecular classification
- Transcription factor, Zinc finger protein, BTB (POZ) domain-containing protein
01
Overview
GDNF-inducible zinc finger protein 1 (GZF1) is a sequence-specific transcriptional repressor characterized by the presence of a BTB/POZ domain and multiple C2H2-type zinc finger motifs[1][4][5]. It is induced by glial cell line-derived neurotrophic factor (GDNF) signaling and binds a defined consensus DNA sequence (known as the GZF1 responsive element, GRE) in the regulatory regions of target genes, such as HOXA10[1]. GZF1 represses transcription by RNA polymerase II in a sequence-specific manner and likely regulates spatial and temporal gene expression during development, particularly in renal morphogenesis[1][5]. It functions primarily in the nucleus and has a role in modulating morphogenesis by acting as a negative regulator of transcription[1][4][5]. Disease associations include joint laxity, short stature, myopia, and certain forms of skeletal dysplasia[5].
- Other names
- GZF1ZBTB23ZNF336JLSMGDNF inducible zinc finger protein 1zinc finger and BTB domain-containing protein 23zinc finger protein 336
02
Biological functions
Transcriptional repressionSequence-specific DNA bindingRegulation of gene expression (notably HOXA10)Negative regulation of transcription by RNA polymerase IIPossible role in developmental morphogenesis (notably renal branching)
03
Disease associations
Joint laxity, short stature, and myopiaDesbuquois dysplasia 1Other (possible developmental and morphogenesis roles)
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