Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
GDP-fucose Biosynthesis
- Molecular classification
- Enzyme, Metabolic pathway
01
Overview
GDP-fucose biosynthesis refers to the cellular processes that generate GDP-L-fucose, a critical sugar nucleotide donor used in the fucosylation of glycans. Fucosylated glycans are essential for various biological functions, including cell signaling and immune responses. There are two main pathways: the de novo pathway (from GDP-mannose via GMDS and TSTA3/FX) and the salvage pathway (from free L-fucose via FUK and FPGT). Regulation involves feedback inhibition and interplay between pathways. After synthesis in the cytosol, SLC35C1 transports UDP-Fuc/GDP-Fuc into the Golgi lumen. The enzymes involved are conserved across many species.
02
Mechanism of action
Inhibition of GDP-fucose synthesis enzymes
03
Biological functions
Glycan modificationCell signalingImmune responseCell-cell communicationFucosylation
04
Disease associations
CancerInflammationInfection
05
Safety considerations
Disruption of glycosylationPotential for off-target effects due to the broad roles of fucosylated glycans
Beyond the preview
Go deeper on GDP-fucose Biosynthesis.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on GDP-fucose Biosynthesis.