GDP-fucose transporter 1 (SLC35C1)

GDP-fucose transporter 1 (SLC35C1) is a member of the solute carrier family 35, functioning as an antiporter responsible for transporting GDP-fucose from the cytoplasm into the Golgi apparatus in exchange for GMP[3][4]. This activity is essential for the fucosylation of glycans, a crucial modification required for proper cell signaling, protein stability, and immune cell adhesion[1][2][3]. Mutations in the SLC35C1 gene cause congenital disorder of glycosylation type IIc (also called leukocyte adhesion deficiency type II), characterized by defective fucosylation, immune dysfunction, growth retardation, and developmental delays[2][3][4]. SLC35C1 is a validated transporter target, but no small-molecule drugs are currently known to directly target or modulate it; therapy in genetic disorders may use fucose supplementation to bypass the transport defect[2]. Its deficiency is diagnostically relevant for immunodeficiencies with glycosylation defects and is often monitored via glycan structure analysis in clinical settings[3][2].

Other names

FUCT1FLJ11320CDG2CGDP-fucose transporterSolute carrier family 35 member C1