Gem-associated protein 7 (GEMIN7)

Gem-associated protein 7 (GEMIN7) is a core component of the **survival of motor neuron (SMN) complex**, which is essential for the assembly of **spliceosomal small nuclear ribonucleoproteins (snRNPs)**, the main building blocks of the spliceosome that catalyzes pre-mRNA splicing in eukaryotic cells[1][2][4][6][7][8]. GEMIN7 localizes to the nucleoplasm, cytoplasm, and distinctive nuclear bodies known as "gems" (Gemini of Cajal bodies)[1][5][8]. It forms a heterodimer with Gemin6, adopting an **Sm protein-like fold** and facilitating the organization and assembly of Sm protein rings on snRNAs[3]. GEMIN7 interacts directly with SMN, Gemin6, and several Sm proteins, playing a critical role in snRNP biogenesis. Dysfunction in components of the SMN complex, including GEMIN7, is implicated in **spinal muscular atrophy** and other neurodegenerative diseases[5]. No drugs or direct mechanisms of action targeting GEMIN7 are currently described, and it is not considered a therapeutic target[1][5][8].

Other names

gem nuclear organelle associated protein 7Gemin-7FLJ13956SIP3gem-associated protein 7gemin-7