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Geminin, DNA replication inhibitor pseudogene
- Molecular classification
- Pseudogene, Non-coding RNA
01
Overview
The entry "Geminin, DNA replication inhibitor pseudogene" (ENSG00000260933; also LOC100133137) refers to a **pseudogene** related to the functional GMNN (Geminin) gene. Pseudogenes do not code for functional proteins and, as such, are not considered direct drug targets, receptors, enzymes, or related classes. However, emerging evidence suggests some pseudogenes can regulate the expression of their cognate functional genes through microRNA competition (acting as "endogenous sponges"), but this function has not been demonstrated specifically for the GMNN pseudogene[4]. The canonical, protein-coding GMNN gene encodes geminin, a nuclear protein involved in cell cycle control and DNA replication regulation[3][1]. The pseudogene does not have an established biological or disease-associated role, nor are there drugs or biomarkers directly attributed to it. **Key clarification:** This entry is a pseudogene, not a protein-coding gene or therapeutic target, and should not be treated as a canonical molecular target for drug development[2][4].
- Other names
- LOC100133137ENSG00000260933geminin pseudogenegeminin, DNA replication inhibitor (pseudogene)
02
Biological functions
Competes for regulatory microRNAs (miRNA decoy function, as described for some pseudogenes)
03
Disease associations
Potential regulatory effects on cognate gene (no direct disease role established)
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