Geminin DNA replication inhibitor (GMNN)

Geminin DNA replication inhibitor (GMNN) is a highly conserved nuclear protein that plays a critical role in cell cycle regulation by inhibiting DNA replication[1][3][5]. Geminin functions primarily by preventing the assembly of the pre-replication complex through inhibition of Cdt1, ensuring that DNA is replicated only once per cell cycle[1][3][4][6]. It accumulates during the S, G2, and M phases and is degraded at the metaphase-anaphase transition by the anaphase-promoting complex[1][3]. Geminin is also involved in regulating cell proliferation, promoting neural differentiation, and safeguarding genomic stability. Overexpression of geminin is found in several malignancies, and its loss can lead to cell death in many cancer cell lines, indicating its potential as a therapeutic target in oncology. However, geminin is essential for embryonic development and normal cell proliferation, which presents therapeutic challenges in selectively targeting cancer cells[1][2][3][4].

Other names

GemininGMNNGemMGORS6gemininGEMI_HUMAN

Inhibition of DNA replication license by blocking interaction of Cdt1 with the pre-replication complex; Cell cycle arrest and apoptosis upon depletion in many cancer cell lines