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Gene Expression Involved in Synaptic Plasticity

Molecular classification: Transcription factor, Immediate Early Gene (IEG), Postsynaptic density protein, Neurotransmitter receptor subunit

Overview

Gene expression involved in synaptic plasticity refers to the dynamic regulation of genes within neurons that underlies the ability of synapses—the connections between nerve cells—to strengthen or weaken over time. This process is fundamental for learning, memory formation, and adaptive neural circuit function. Key genes include Arc, Egr1, CREB, Gria2/Gria3, and NR2B. Disruption or deregulation of these gene networks is implicated in neurodegenerative diseases such as Alzheimer’s disease.

Biological functions

Synaptic plasticityLearningMemory formationRegulation of postsynaptic density proteinsDendritic spine morphologyNeurotransmitter receptor traffickingSynapse formation/eliminationMemory consolidationActivity-dependent gene expression

Disease associations

Neurodegenerative diseaseAlzheimer's diseaseCognitive disorders

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