Gene transfer to airway epithelial cells

Gene transfer to airway epithelial cells refers to the process of introducing genetic material into the epithelial cells that line the respiratory tract. This approach is of high research and clinical interest for treating genetic lung diseases such as cystic fibrosis. Methods include both viral (e.g., adenovirus, adeno-associated virus, lentivirus) and non-viral (e.g., cationic lipid, electroporation) vectors, as well as physical or chemical airway preparation to overcome barriers like mucus, tight junctions, and apically restricted receptor availability[1][2][3][4][6][7]. The process involves delivering the genetic material to achieve expression of therapeutic genes in target airway cells, but is complicated by host defense mechanisms, inefficient vector uptake, and potential immune responses.

Other names

Gene delivery to airway epithelial cellsAirway epithelial gene transferAirway gene delivery