General biomolecules in blood and tissues

General biomolecules in blood and tissues is a broad, non-specific term encompassing the entire range of endogenous substances found within the human body, including proteins, lipids, carbohydrates, and metabolites (IUPHAR/BPS Guide to Pharmacology, 2024). This designation does not refer to a single, specific therapeutic target such as a receptor, enzyme, or transporter, but rather describes the collective biological environment in which pharmacological agents operate (Nature Reviews Drug Discovery, 2006). In drug discovery and development, a valid target must be a discrete molecular entity that can be modulated to achieve a specific physiological outcome (NIH National Center for Advancing Translational Sciences, 2023). Because this term lacks molecular specificity and encompasses nearly all biological matter, it is considered an incorrect or overly broad classification for a therapeutic target (PubChem, 2024). Drugs are designed to interact with specific molecular structures to minimize off-target effects and systemic toxicity (StatPearls, 2023). Consequently, this entry serves as a general category for physiological components rather than a defined point of pharmacological intervention.

Other names

Endogenous substancesBiological moleculesPhysiological componentsEndogenous biomolecules

Not applicable as this is not a specific molecular target.