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General transcription factor IIE subunit 1 (GTF2E1)
- Target
- GTF2E1
- Molecular classification
- Transcription factor
01
Overview
General transcription factor IIE subunit 1 (GTF2E1), also known as TFIIE-alpha, is a protein component of the general transcription factor TFIIE complex, which is essential for transcription initiation by RNA polymerase II in eukaryotes[3][8][1][10]. GTF2E1 recruits the TFIIH complex to the transcriptional initiation complex and stimulates its C-terminal domain kinase and DNA-dependent ATPase activities, both of which are necessary for promoter clearance by RNA polymerase II[4][9][10]. This factor is ubiquitously expressed and functions as part of the basal transcription machinery in the nucleus. Disruption or altered regulation of GTF2E1 has been reported in certain rare genetic disorders and may be regulated in cancer, but it is not currently considered a direct therapeutic target[3][5][9].
- Other names
- General transcription factor IIE subunit 1GTF2E1TFIIE-alphaTFIIE-AFEGeneral transcription factor IIE 56 kDa subunitTranscription initiation factor IIE subunit alphaTFIIE alpha subunitgeneral transcription factor IIE polypeptide 1 alpha 56 kDaTF2E1T2EA
02
Biological functions
Transcription initiation by RNA polymerase IIRecruitment of TFIIH to transcription initiation complexStimulation of kinase and DNA-dependent ATPase activities of TFIIH
03
Disease associations
Rare associations with neurodevelopmental disorders (e.g., Spastic paraplegia 70, autosomal recessive; Autosomal recessive Robinow syndrome)Reported regulation in some cancers (e.g., colorectal cancer, lung adenocarcinoma) by downstream literature
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