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General transcription factor IIF subunit 1 (GTF2F1)
- Target
- GTF2F1
- Molecular classification
- Transcription factor
01
Overview
General transcription factor IIF subunit 1 (GTF2F1) is a protein encoded by the GTF2F1 gene in humans. As part of the TFIIF complex, it binds to RNA polymerase II and is essential for recruiting the polymerase to the initiation complex during the process of transcription initiation by RNA polymerase II. It interacts with several other components of the transcription machinery, including CTDP1, GTF2H4, HNRPU, MED21, POLR2A, serum response factor, TAF11, TAF1, TATA binding protein, and Transcription Factor II B[1][2][6]. There are currently no known drugs that directly target GTF2F1, and it is not recognized as a therapeutic target in drug development.
- Other names
- RAP74TFIIF-alphaTFIIFBTF4TF2F1General transcription factor IIF 74 kDa subunitTranscription initiation factor IIF subunit alphaTranscription initiation factor RAP74
02
Biological functions
Transcription initiationBinding to RNA polymerase IIRecruitment of RNA polymerase II to the initiation complex
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