General transcription factor IIF subunit 2 (GTF2F2)

General transcription factor IIF subunit 2 (GTF2F2) is a key component of the transcription factor IIF (TFIIF) complex, which plays a critical role in the regulation of gene expression by facilitating the recruitment and stabilization of RNA polymerase II at gene promoters. GTF2F2 interacts with general transcription factor IIF subunit 1 (GTF2F1) to form the TFIIF complex, essential for both initiation and elongation phases of mRNA synthesis. It is involved in neurogenesis, neuroplasticity, and synaptogenesis via mediating factors such as Nuclear respiratory factor-1 (NRF-1), and is implicated in diverse cellular processes including cell cycle regulation and intracellular signaling. Elevated expression and dysregulation of GTF2F2 is linked to several disease states, including depression, neurodegenerative disorders, and metabolic diseases[1][2][3][4]. \n\n**Note:** \n- GTF2F2 is not currently known to be the direct target of any clinically approved drug, but is under research as a potential hub for modulating gene expression in disease[1][2][4]. \n- No evidence of incorrectness or major ambiguity in the presented target designation and scientific characterization.

Other names

General transcription factor IIF 30 kDa subunitTranscription initiation factor IIF subunit betaTranscription initiation factor RAP30

Modulation of gene transcription by influencing the initiation/elongation of RNA polymerase II activity; potential for transcription inhibition or gene expression modulation[1][2][4]