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Target intelligence / Profile preview
General transcription factor IIH subunit 1 (GTF2H1)
- Target
- GTF2H1
- Molecular classification
- Transcription factor, Component of basal transcription machinery
01
Overview
General transcription factor IIH subunit 1 (GTF2H1) is a core component of the TFIIH complex, which is essential for both RNA polymerase II-mediated transcription initiation and nucleotide excision repair of damaged DNA. It plays a key role in opening DNA at promoters to allow transcription initiation and participates in the DNA repair process by facilitating the excision of damaged DNA fragments and their subsequent replacement. GTF2H1 also enables interactions with nuclear receptors and other transcriptional regulators, with disruption of its function linked to disease processes, particularly those related to DNA repair deficiency and transcriptional dysregulation.
- Other names
- BTF2BTF2 p62p62TFB1TFIIHgeneral transcription factor IIH polypeptide 1TFIIH basal transcription factor complex p62 subunitbasic transcription factor 2 62 kDa subunit
02
Mechanism of action
Inhibition of DNA repair (sensitizes cells to DNA-damaging agents)
03
Biological functions
DNA repair (nucleotide excision repair)Transcription initiation by RNA polymerase IIPromoter opening and promoter escapeRegulation of transcriptionNuclear hormone receptor binding (e.g., thyroid hormone receptor)
04
Disease associations
Cancer (implicated through DNA repair and transcription disruption)Viral infection (HIV transcription complex)Other (e.g., associated with Rift Valley fever, Phlebotomus fever as related genes)
05
Safety considerations
Risk of impaired DNA repair leading to increased mutagenesis or sensitivity to genotoxic stressPotential effects on normal transcription and cell viability if targeted systemically
06
Interacting drugs
Cisplatin (sensitization via DNA repair modulation)
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