General transcription factor IIH subunit 2-like protein (GTF2H2C)

General transcription factor IIH subunit 2-like protein (GTF2H2C) is a component of the core TFIIH basal transcription factor complex. It is predicted to enable zinc ion binding, participate in nucleotide excision repair (NER) of DNA, and play a role in the regulation of transcription by RNA polymerase II. GTF2H2C is localized to nuclear specks, functions in the assembly of the TFIIH complex, and interacts with other components integral to transcription and DNA repair[1][2][3][5].\n\nInterpretation notes:\n- GTF2H2C is primarily a structural and regulatory component of the TFIIH complex necessary for gene transcription and DNA repair; there is no robust evidence supporting its use as a direct therapeutic target, receptor, or druggable protein[1][2][3][5].\n- No documented direct drug interactions, mechanisms of action, biomarkers, or therapy-linked safety concerns were found in the available search results.\n- The gene may have disease relevance due to its role in DNA repair and gene regulation, but it is not considered a primary disease target or clinically actionable biomarker.

Other names

General transcription factor IIH polypeptide 2-like proteinGTF2H2DGTF2H2C_2general transcription factor IIH, polypeptide 2CT2H2L