General transcription factor IIIC subunit 1 (GTF3C1)

General transcription factor IIIC subunit 1 (GTF3C1) is a core component of the TFIIIC multiprotein complex, crucial for the initiation of transcription of small noncoding RNA genes—including tRNA and 5S rRNA genes—by RNA polymerase III. GTF3C1 recognizes internal promoter elements and helps recruit the Pol III machinery to its targets. The protein integrates signals from nutrient and stress-related pathways, notably through interactions with kinases such as mTOR and chromatin regulators like SIRT7, thereby linking cellular metabolic state to ribosome biogenesis and protein synthesis. Disruption or dysregulation of GTF3C1 may contribute to altered growth or tumor biology due to its pivotal role in controlling the transcription of components required for protein translation[1][2][4][7].

Other names

General transcription factor 3C polypeptide 1TFIIIC 220 kDa subunitTFIIIC220TF3C-alphaTFIIIC box B-binding subunitTranscription factor IIIC 220 kDa subunitTranscription factor IIIC subunit alphaTFIIICTFIIICalphaTFIIICALPHA