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Target intelligence / Profile preview
General transcription factor IIIC subunit 2 (GTF3C2)
- Target
- GTF3C2
- Molecular classification
- Transcription factor, RNA polymerase III initiation factor, WD40-repeat containing protein
01
Overview
General transcription factor IIIC subunit 2 (GTF3C2) is a protein component of the transcription factor IIIC (TFIIIC) complex, which is essential for RNA polymerase III-mediated transcription. GTF3C2 contributes to DNA binding and the assembly of the transcription initiation complex on tRNA genes and other small RNA genes transcribed by RNA polymerase III. This protein contains WD40 repeats, a structural motif involved in protein–protein interactions, and is predominantly localized to the nucleus as part of the TFIIIC complex. There is currently no evidence it serves as a therapeutic target or interacts with any approved drugs[1][2][3][4][5][7][8].
- Other names
- General transcription factor 3C polypeptide 2KIAA0011TFIIIC 110 kDa subunitTFIIIC110TF3C-betaTranscription factor IIIC subunit betaTFIIIC-BETA
02
Biological functions
Transcription by RNA polymerase IIIDNA bindingTranscription initiation complex assembly on tRNA genes
03
Disease associations
Other
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