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Target intelligence / Profile preview
General transcription factor IIIC subunit 5 (GTF3C5)
- Target
- GTF3C5
- Molecular classification
- Transcription factor, DNA-binding protein, TFIIIC2 complex subunit
01
Overview
General transcription factor IIIC subunit 5 (GTF3C5) is a component of the multi-subunit transcription factor IIIC complex, which is essential for RNA polymerase III-mediated transcription. This protein directly binds DNA sequence motifs in promoters of tRNA and other small RNAs, guiding RNA polymerase III to the initiation site. GTF3C5 is considered a tightly associated, integral element of the TFIIIC2 subcomplex and plays a crucial role in the transcriptional regulation of genes involved in cellular differentiation and ribosomal biosynthesis. It localizes to the nucleus and interacts with other TFIIIC complex proteins, including GTF3C2 and GTF3C4. Disease roles are limited and largely associative, with minimal evidence for direct involvement in major human diseases. No known drugs interact directly with this protein, and it does not serve as a biomarker or safety concern in clinical settings.
- Other names
- General transcription factor 3C polypeptide 5GTF3C5TFIIIC 63 kDa subunitTFIIIC63TFIIICepsilonTFiiiC2-63TF3C-epsilon
02
Mechanism of action
Not applicable; no pharmacologic agents known to target this gene/protein
03
Biological functions
RNA polymerase III general transcription initiationSequence-specific DNA binding at class III gene promotersFacilitates transcription of 5S rRNA and tRNA genesProtein binding (component interactions within TFIIIC complex)Associated with cell differentiation
04
Disease associations
Some genetic association with Hypomelanosis of ItoHerpetic Whitlow (listed as associated, likely as gene location not direct causal role)No well-established or direct major disease mechanism roles cited in current data
05
Safety considerations
None documented; not an active therapeutic or diagnostic target so no safety data applicable
06
Interacting drugs
None known; no drugs reported to directly target GTF3C5
07
Biomarkers
None established for this target
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