Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
General vesicular transport factor p115 (USO1)
- Target
- USO1
- Molecular classification
- Other (vesicular transport/tethering factor)
01
Overview
General vesicular transport factor p115 (USO1) is a peripheral membrane protein required for vesicular transport from the endoplasmic reticulum (ER) to the Golgi apparatus and for intercisternal transport within the Golgi stack. It is regulated by phosphorylation; dephosphorylated p115 associates with Golgi membranes, while phosphorylation causes dissociation. USO1 acts as a tethering factor, bringing COPII vesicles into proximity with target Golgi membranes by interacting with vesicle-associated SNARE proteins to promote fusion and trafficking through the early secretory pathway. Although essential for vesicle trafficking and Golgi integrity, it is not recognized as a direct therapeutic target and no drugs are known to interact with it[1][4][7].
- Other names
- USO1 vesicle transport factorUSO1VDPTAPp115Protein USO1 homologTranscytosis-associated proteinVesicle-docking proteinVesicle docking proteinTranscytosis associated proteinUSO1 vesicle docking protein homologVesicle docking protein p115
02
Biological functions
Vesicle tetheringER-to-Golgi transportGolgi apparatus organizationVesicle docking
03
Disease associations
Retinal diseaseHypogonadotropic hypogonadism 14 with or without anosmiaOther (no strong therapeutic association)
Beyond the preview
Go deeper on General vesicular transport factor p115 (USO1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on General vesicular transport factor p115 (USO1).