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Genetically Modified Porcine Kidney (N/A)
- Target
- N/A
- Molecular classification
- Whole Organ, Xenograft
01
Overview
A genetically modified porcine kidney intended for xenotransplantation into human recipients with end-stage kidney disease. Genetic modifications aim to reduce immunogenicity, prevent PERV transmission, and improve compatibility with the human immune system. It serves as a replacement organ to restore renal function.
- Other names
- Gene-edited pig kidneyXenotransplant kidneyUKidney™
02
Mechanism of action
Replacement of non-functional kidneys with a genetically modified porcine kidney to restore renal function; Immunosuppression to prevent rejection of the xenograft.
03
Biological functions
Renal filtrationWaste removalFluid balanceElectrolyte balanceHormone production (e.g., erythropoietin)Blood pressure regulation
04
Disease associations
End-stage kidney disease (ESKD)End-stage renal disease (ESRD)Kidney failure
05
Safety considerations
Hyperacute rejectionAcute rejectionChronic rejectionPorcine endogenous retrovirus (PERV) transmissionGraft overgrowthImmunosuppression-related complications (e.g., infection, malignancy)Ureteral complications
06
Interacting drugs
Monoclonal antibody immunosuppressants (e.g., anti-CD40 antibodies)
4 more in the full profile.
07
Biomarkers
Serum creatinineBlood urea nitrogen (BUN)Glomerular filtration rate (GFR)ProteinuriaDonor-specific antibodies (DSA)Markers of immune activation (e.g., cytokines)
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