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Genomic double-stranded DNA (DNA)
- Target
- DNA
- Molecular classification
- Other
01
Overview
Genomic double-stranded DNA serves as the molecular target for SG3199, a pyrrolobenzodiazepine (PBD) dimer. SG3199 forms covalent interstrand cross-links within the minor groove of DNA, primarily at guanine bases, disrupting DNA replication and transcription, leading to cell cycle arrest and apoptosis. Its effectiveness is influenced by factors like ERCC1 and SLFN11 expression levels in tumor cells. SG3199 is a component of antibody-drug conjugates like Tesirine.
- Other names
- Double-stranded DNAdsDNA
02
Mechanism of action
Covalent minor groove binding; induces interstrand cross-links, blocking replication and transcription.
03
Biological functions
ReplicationTranscriptionGenetic information storageOther
04
Disease associations
Cancer
05
Safety considerations
High plasma protein bindingRapid clearancePotential for off-target effects
06
Interacting drugs
SG3199
1 more in the full profile.
07
Biomarkers
ERCC1 expressionSLFN11 expression
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