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DNA Damage (N/A)
- Target
- N/A
- Molecular classification
- Other
01
Overview
DNA damage refers to any alteration in the chemical structure of DNA that impairs its normal function in transcription or replication. This includes modifications such as strand breaks, missing nucleobases, chemically altered bases, abasic sites, adducts, single-strand breaks (SSBs), double-strand breaks (DSBs), DNA-protein cross-links, and insertion/deletion mismatches. DNA damage can arise from endogenous metabolic processes or exogenous environmental factors. Unrepaired damage can lead to mutations, cell death, or cancer.
- Other names
- DNA lesionsGenomic instabilityGenetic damage
02
Mechanism of action
N/A
03
Biological functions
Cell cycleApoptosisDNA repairSenescenceGenome maintenance
04
Disease associations
CancerAgingNeurodegenerative diseaseGenetic disorders
05
Safety considerations
GenotoxicityMutagenesisCarcinogenesis
06
Biomarkers
8-OHdGγH2AXMicronuclei
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