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Target intelligence / Profile preview
Genomic nuclear double-stranded DNA (DNA)
- Target
- DNA
- Molecular classification
- Nucleic Acid
01
Overview
Genomic nuclear double-stranded DNA is the primary molecular target of carboplatin. Carboplatin, a platinum-based chemotherapeutic agent, exerts its cytotoxic effects by binding to DNA and forming covalent adducts, leading to DNA crosslinking. The formation of these crosslinks disrupts essential cellular processes such as DNA replication and transcription, ultimately leading to cell death through apoptosis or necrosis.
- Other names
- Deoxyribonucleic acidNuclear DNA
02
Mechanism of action
Covalent binding at N7 position on purine bases; forms mono-, intra-, interstrand links, blocking replication and transcription
03
Biological functions
ReplicationTranscriptionGenome maintenanceGenetic information storage
04
Disease associations
CancerGenetic disorders
05
Safety considerations
Drug resistanceOff-target DNA damageSecondary malignancies
06
Interacting drugs
Carboplatin
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