Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Geranylgeranyl pyrophosphate synthase
- Molecular classification
- Enzyme, Prenyltransferase
01
Overview
Geranylgeranyl pyrophosphate synthase (GGPPS) is an enzyme that catalyzes the synthesis of geranylgeranyl pyrophosphate (GGPP) from farnesyl diphosphate (FPP) and isopentenyl diphosphate (IPP). GGPP is a 20-carbon isoprenoid molecule essential for the post-translational modification of proteins via geranylgeranylation and as a precursor for vitamin K2, ubiquinone, carotenoids, gibberellins, tocopherols, and chlorophylls. Dysregulation or mutations in GGPS1 are linked to several human diseases, including cancer and pulmonary fibrosis. GGPPS inhibitors are under investigation as potential therapeutics.
- Other names
- GGPPSGGDPSGeranylgeranyl diphosphate synthaseMDHLO/MUDHLOV
02
Mechanism of action
Inhibition of protein geranylgeranylation
03
Biological functions
Isoprenoid biosynthesisProtein geranylgeranylationProduction of GGPPRegulation of nuclear hormone receptors
04
Disease associations
Muscular dystrophyHearing lossOvarian insufficiencyLiver diseaseType 2 diabetesPulmonary diseaseCancer
05
Safety considerations
Potential for off-target effects due to the broad role of GGPP in cellular processesInhibition of essential metabolic pathways
06
Interacting drugs
Bisphosphonates
1 more in the full profile.
Beyond the preview
Go deeper on Geranylgeranyl pyrophosphate synthase.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Geranylgeranyl pyrophosphate synthase.