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Target intelligence / Profile preview
Geranylgeranyltransferase type I (GGTase-I)
- Target
- GGTase-I
- Molecular classification
- Enzyme, Transferase, Prenyltransferase
01
Overview
Geranylgeranyltransferase type I (GGTase-I) is an essential eukaryotic enzyme that catalyzes the posttranslational modification of proteins by transferring a geranylgeranyl group to the cysteine residue within a C-terminal CaaX motif of target proteins. This facilitates membrane association and proper function of numerous signaling proteins, especially those involved in cell regulation and oncogenesis. GGTase-I is a heterodimer composed of two subunits: alpha (FNTA gene) and beta (PGGT1B gene). It modifies more than 100 different proteins, including many small GTP-binding regulatory proteins such as members of the Rho family and some Ras-related proteins. Due to its role in cancer progression, inhibition of GGTase-I has been explored as an anti-cancer strategy.
- Other names
- Protein Geranylgeranyltransferase Type I
02
Mechanism of action
Inhibition of geranylgeranylation of target proteins, particularly Rho family GTPases.
03
Biological functions
Posttranslational modificationMembrane associationRegulation of small GTPasesCell signalingProtein prenylation
04
Disease associations
Cancer progressionMetastasisOncogenesis
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