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Target intelligence / Profile preview
Germ cell-associated 1 (GSG1)
- Target
- GSG1
- Molecular classification
- Other (predicted nucleic acid/protein interactor; not classified as receptor, enzyme, transporter, ion channel, or transcription factor)
01
Overview
Germ cell-associated 1 (GSG1) is a protein predominantly expressed in the human testis, integral to spermatogenesis and germ cell development. It is predicted to enable RNA polymerase binding activity and localize to the endoplasmic reticulum and plasma membrane. Low GSG1 expression has been linked to worse outcomes in liver cancer, possibly modulated by estrogen, identifying it as a negative prognostic biomarker in this context. In testicular tissue, GSG1 is important for the maturation of germ cells, and its altered expression may serve as a diagnostic marker for male infertility, especially non-obstructive azoospermia. There are currently no known direct drug interactions, mechanisms of action, or safety concerns for GSG1 as a therapeutic target; instead, its clinical utility lies primarily in disease diagnosis and prognosis rather than pharmacologic intervention.
- Other names
- Germ cell-specific gene 1 proteinTesticular secretory protein Li 20UNQ709/PRO1360MGC3146GSG1
02
Biological functions
RNA polymerase binding (predicted)Spermatogenesis and spermatid developmentGerm cell maturationCellular localization to endoplasmic reticulum and plasma membrane
03
Disease associations
Cancer (low expression as a negative prognostic biomarker in liver cancer)Male infertility (diagnostic marker for spermatogenesis dysfunction and azoospermia)
04
Biomarkers
Prognostic biomarker for liver cancer (low expression/poor outcome)Diagnostic marker for male infertility, especially non-obstructive azoospermia
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