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Target intelligence / Profile preview
Germinal center associated signaling and motility protein (GCSAM)
- Target
- GCSAM
- Molecular classification
- Other (adapter/signaling protein)
01
Overview
Germinal center associated signaling and motility protein (GCSAM) is a cytoplasmic signaling adapter highly expressed in germinal center B cells, where it plays key roles in signal transduction and cell motility regulation. The protein contains a PDZ-interacting domain, immunoreceptor tyrosine-based activation motif (ITAM), and putative SH2-binding sites. GCSAM is specifically induced by interleukin-4 and is involved in negatively regulating lymphocyte motility and B-cell receptor signaling via activation of the SYK kinase and the RhoA/ROCK pathway. Its expression is notably elevated in germinal center-derived lymphomas and is used as a marker for germinal center B cells[1][6].
- Other names
- Germinal center-associated signaling and motility proteinGCET2HGALMGC40441Germinal center B-cell-expressed transcript 2 proteinGerminal center-associated lymphoma proteinHuman germinal center-associated lymphomaGCAT2Germinal center expressed transcript 2hGALGAL
02
Biological functions
Signal transductionRegulation of lymphocyte motilityMigration-inhibitory signalingPositive regulator of the RhoA signaling pathwayB-cell receptor signaling regulator
03
Disease associations
Cancer (notably B-cell lymphoma, large B-cell lymphoma)Other (lymphoma)
04
Biomarkers
GCSAM protein expression is a biomarker of germinal center B cells and has been studied as a diagnostic/prognostic marker in B-cell lymphoma
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