GH3 domain containing protein (GHDC)

GH3 domain containing protein (GHDC) is a human gene located on chromosome 17 at 17q21.31, with aliases including LGP1 and other variants reflecting sequence similarity with mouse LGP1. The “GH3 domain” generally refers to a structural motif first described in enzymes like glycoside hydrolases, but in humans, the GHDC gene is poorly characterized and does not correspond to well-defined glycoside hydrolase family members or recognized therapeutic targets. Unlike the functional GH3 enzymes described in other contexts (e.g., in plants, fungi, or bacteria, where they catalyze glycan hydrolysis), the human GHDC protein does not have assigned enzymatic, receptor, transporter, or transcriptional functions, nor does it have a documented role in cell signaling, disease biology, or pharmacology in human medicine. There is no evidence that GHDC in humans functions as a glycoside hydrolase or classic therapeutic target. The GHDC gene has multiple transcript variants with uncertain functional implications. Its naming overlaps with better-studied “GH3 domain” proteins in other organisms; in those contexts, the GH3 domain is involved in carbohydrate-active enzyme activity, but that is not established for human GHDC. The target may be misclassified or lacks functional data for structured pharmacological contexts, so it should not be considered a canonical therapeutic target. If more functional, disease, or pharmacological information becomes available for human GHDC, the above attributes may need to be updated accordingly.

Other names

D11LGP1ELGP1D11LGP1GH3 domain-containing proteinhomolog of mouse LGP1