Gibbon Ape Leukemia Virus Glycoprotein R- (GALV-GP R-)

GALV-GP R- is a fusogenic membrane glycoprotein derived from the gibbon ape leukemia virus. It is engineered into oncolytic viruses, such as herpes simplex virus-1 (HSV-1), to enhance their ability to kill tumor cells through cell-cell fusion and immunogenic cell death. This protein induces syncytia formation, leading to tumor cell lysis and the release of danger-associated molecular patterns (DAMPs), which stimulate an anti-tumor immune response.

Other names

GALV-GP RFusogenic membrane glycoprotein from Gibbon Ape Leukemia Virus

Induces cell-cell fusion and syncytia formation in tumor cells, leading to cell lysis and release of DAMPs, which promotes an anti-tumor immune response.