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Gigaxonin (GAN)
- Target
- GAN
- Molecular classification
- BTB/kelch repeat protein, E3 ubiquitin ligase adaptor
01
Overview
Gigaxonin (GAN), also known as Kelch-like protein 16 (KLHL16), is an adaptor protein for Cul3-E3 ubiquitin ligases. It plays a crucial role in regulating the turnover of intermediate filament (IF) proteins, including neurofilaments, vimentin, keratins, and GFAP. Mutations in GAN cause giant axonal neuropathy (GAN), characterized by abnormal accumulation of neurofilaments. Recent research suggests a potential role as a tumor suppressor in head and neck cancers.
- Other names
- Kelch-like protein 16KLHL16
02
Biological functions
UbiquitinationProtein degradationCytoskeletal regulationIntermediate filament turnover
03
Disease associations
Giant axonal neuropathyCancer
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