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GINS complex subunit 3 (GINS3)
- Target
- GINS3
- Molecular classification
- DNA replication complex subunit, Other (replication fork machinery)
01
Overview
GINS complex subunit 3 (GINS3, also known as PSF3) is a core component of the heterotetrameric GINS complex in eukaryotes, composed of Sld5, Psf1, Psf2, and Psf3 (GINS3). The GINS complex is essential for both the initiation and elongation of DNA replication by physically associating with the replicative helicase (MCM2–7) and Cdc45 to form the CMG complex, the central engine of eukaryotic DNA unwinding. GINS3 contributes to the stability and function of the complex and directly interacts with other replisome components. Structurally, the GINS subunits form a stable ring-like tetramer, and Psf3 (GINS3) contains α-helical and β-sheet domains, with flexible regions implicated in partner interactions. As a conserved replication factor, GINS3 is critical for cell proliferation, and while not directly targeted by current drugs, it is increasingly studied in the context of cancer biology due to its essential role in DNA replication and cell cycle progression[1][2][3][4][5].
- Other names
- DNA replication complex GINS protein PSF3PSF3FLJ13912GINS complex subunit 3 (Psf3 homolog)
02
Biological functions
DNA replicationDNA replication initiationDNA replication elongationAssembly of replicative helicase complex (CMG)
03
Disease associations
Cancer (emerging evidence for roles in proliferative diseases)Other (as a core replication factor, possible roles in broad disease contexts associated with replication stress)
04
Safety considerations
Essential for DNA replication—direct inhibition likely to be cytotoxic to all dividing cellsPotential risk for toxicity if targeted in therapy
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