GIPC PDZ domain containing family member 1 (GIPC1)

GIPC1 is a 333-amino-acid scaffolding protein (~36 kDa) containing a central PDZ domain, a GH1 domain, and a GH2 domain[1][2][3]. It mediates specific protein–protein interactions, particularly with the C-termini of G protein signaling regulators (e.g., RGS-GAIP/RGS19), transmembrane receptors (IGF1R, TGFβR3, GLUT1, SDC4, NTRK1, ADRB1, DRD2, integrin α5, NRP1), cytosolic signaling proteins (APPL1), motor proteins (myosin VI/MYO6), and viral proteins (HPV-18 E6, HBc, HTLV-1 Tax)[2][1][4]. GIPC1 is distributed throughout the cytosol and membrane pools and plays a critical role in trafficking, signal attenuation (by interacting with inhibitory Gα signaling), and assembly of multimeric complexes for signal propagation[1][2][5]. Overexpression of GIPC1 is associated with several cancers, while loss-of-function mutations cause specific inherited myopathies[5].

Other names

SynectinC19orf3RGS19IP1TIP-2GAIP interacting protein C-terminus

Drugs/disruptors may act by blocking PDZ domain-mediated interactions, thereby impeding trafficking or signaling linked to tumor progression. Potential antagonists would interfere with GIPC1’s adaptor function or its interaction with signaling proteins and viral ligands.