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Target intelligence / Profile preview
Glial cell-derived neurotrophic factor family receptor alpha-like (GFRAL)
- Target
- GFRAL
- Molecular classification
- Receptor
01
Overview
GFRAL is a receptor belonging to the GDNF receptor family, specific to GDF15. Upon binding, it forms a complex with the RET tyrosine kinase, modulating appetite and energy homeostasis. Primarily expressed in the area postrema and nucleus tractus solitarius of the brainstem, GFRAL is a promising therapeutic target for obesity and cachexia. Blocking the GDF15-GFRAL-RET pathway shows promise in reversing cachexia symptoms.
02
Mechanism of action
Agonists for obesity treatment, antagonists for cachexia therapy
03
Biological functions
Signal transductionAppetite regulationEnergy homeostasis
04
Disease associations
ObesityCachexiaAnorexia
05
Safety considerations
Potential for affecting appetite and metabolism
06
Biomarkers
GDF15
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