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Target intelligence / Profile preview
Glial cell-derived neurotrophic factor receptor alpha-like (GFRAL)
- Target
- GFRAL
- Molecular classification
- Receptor, GDNF family receptor, Signaling receptor
01
Overview
Glial cell-derived neurotrophic factor receptor alpha-like (GFRAL) is a signaling receptor that forms a complex with the RET tyrosine kinase upon binding to its ligand, Growth Differentiation Factor 15 (GDF15). This interaction primarily occurs in neurons of the area postrema and nucleus tractus solitarius in the brainstem and plays a crucial role in appetite regulation and energy homeostasis. As such, GFRAL represents a potential therapeutic target for conditions like obesity, anorexia, and cancer-related cachexia.
02
Mechanism of action
GDF15 binding to GFRAL induces RET tyrosine kinase activation, triggering downstream signaling pathways affecting energy balance and feeding behavior.
03
Biological functions
Signal transductionAppetite regulationEnergy homeostasisGDNF family receptor activityReceptor tyrosine kinase binding
04
Disease associations
ObesityAnorexiaCachexiaCancer
05
Safety considerations
Potential for off-target effects due to the restricted but not exclusive expression of GFRAL.Unintended consequences of manipulating appetite and energy homeostasis.
06
Biomarkers
GDF15 levels (as a potential predictive marker for cachexia or response to GFRAL-targeting therapies)
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