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Target intelligence / Profile preview
Glial cell line-derived neurotrophic factor family receptor alpha 1 (GFRA1)
- Target
- GFRA1
- Molecular classification
- Receptor, Glycosylphosphatidylinositol (GPI)-anchored cell surface receptor
01
Overview
Glial cell line-derived neurotrophic factor family receptor alpha 1 (GFRA1), also known as GFRα1, is a glycosylphosphatidylinositol (GPI)-anchored cell surface receptor that plays a critical role in neuronal survival and differentiation. It acts as a coreceptor for GDNF, NRTN, ARTN, and PSPN, and upon ligand binding, forms a ternary complex with the RET tyrosine kinase coreceptor, activating downstream signaling pathways such as Ras/MAPK and PI3K/Akt.
- Other names
- GDNF family receptor alpha-1GDNFRGDNFRAGFR-ALPHA-1RET1LRETL1TRNR1
02
Biological functions
Neuronal survivalNeuronal differentiationSignal transduction
03
Disease associations
Hirschsprung diseaseTumorigenesisColon cancer
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