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Target intelligence / Profile preview
Glial Cell Line-Derived Neurotrophic Factor Family Receptor Alpha-3 (GFRα3)
- Target
- GFRα3
- Molecular classification
- Receptor, GPI-linked cell surface glycoprotein, GDNF receptor family, Transforming growth factor-beta (TGF-beta) superfamily subgroup
01
Overview
Glial cell line-derived neurotrophic factor family receptor alpha-3 (GFRα3) is a glycosylphosphatidylinositol (GPI)-anchored cell surface receptor and a member of the GDNF receptor family. It functions as a co-receptor with RET tyrosine kinase to transduce signals from its ligand, Artemin, into intracellular responses, affecting neuronal survival, differentiation, migration, and tissue maturation. In the absence of RET, signaling can also occur via NCAM. It plays a role in development and has been implicated in cancer.
- Other names
- GFRA3
02
Biological functions
Signal transductionNeuronal survivalNeuronal maintenancePeripheral nervous system developmentOrganogenesis
03
Disease associations
Cancer
04
Safety considerations
Aberrant activation implicated as an oncogenic promoter
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